One of the largest studies of its kind has found women who use over-the-counter painkillers in pregnancy are around one and half times more likely to have a baby with health issues. The risk of a preterm delivery, stillbirth or neonatal death, physical defects and other problems are all higher compared with the offspring of mothers who did not take these drugs.
A large cohort study drawn from the national IVF registry of France, which included almost 70,000 pregnancies delivered after 22 weeks gestation between 2013 and 2018, has found a higher risk of pre-eclampsia and hypertension in pregnancies derived from frozen-thawed embryos. This risk was found significantly greater in those treatments in which the uterus was prepared for implantation with hormone replacement therapies. The results confirm with real-life data what has been observed in sub-groups of patients in other studies.
A new report raises serious questions about the benefits, risks and ethics of a new service -- which the authors call "embryo selection based on polygenic scores," or ESPS -- that allows in vitro fertilization patients to select embryos with the goal of choosing healthier and even smarter children.
A large cohort study from the national IVF registry of Sweden, which included almost 125,000 treatments carried out between 2007 and 2017, has concluded that the steady rise in birth rates can be attributed to two emerging clinical trends in IVF: the transfer of embryos at the blastocyst stage of their development and the increasing use of embryo freezing (with the fast-freeze technology of vitrification).
Cancer treatments can cause premature ovarian failure (POI) including in girls who want to become mothers eventually. Ovarian tissue cryopreservation (OTC) provides a future fertility option but is invasive, has risks and evidence indicates that most girls don't develop POI. So, doctors face the dilemma of how to offer OTC appropriately. An assessment tool has been found to help predict correctly which female cancer patients aged under 18 years will develop POI and should therefore be offered OTC.
Studies indicate that the optimal and safe number of oocytes needed for achieving an ongoing pregnancy is between six and 15. A retrospective observational study suggests that IVF clinics in the UK may be retrieving "far too many oocytes" and that most of them "may never be used and are probably discarded".
Fertility patients who have a poor response to ovarian stimulation represent a stubborn challenge in IVF. Clinical guidelines indicate that increasing the drug dose for stimulation or applying any of several adjunct therapies are of little benefit. A study assessing two cycles of ovarian stimulation and two egg collections in the same menstrual cycle may yet provide a real advance for predicted poor responders in IVF.
Black men most likely to benefit from advanced prostate cancer therapies are 11% less likely to get them than non-Black men.
The research finds that the atypical centriole in the sperm neck acts as a transmission system that controls twitching in the head of the sperm, mechanically synchronizing the sperm tail movement to the new head movement.
The risk of cancer in children born as a result of fertility treatment has been found to be no greater than in the general population. An 18-year median follow up study demonstrates that the overall chance of developing malignant disease did not increase in ART-conceived offspring.