New research has shown that results of blood tests routinely performed by GPs everywhere contain a hidden fingerprint that can identify people silently developing potentially fatal liver cirrhosis. The researchers have developed an algorithm to detect this fingerprint that could be freely installed on any clinical computer, making this a low-cost way for GPs to carry out large scale screening using patient data they already hold.
One of the many mysteries still surrounding COVID-19 is why some people experience only mild, flu-like symptoms, whereas others suffer life-threatening respiratory problems, vascular dysfunction and tissue damage. Now, researchers reporting in ACS' Analytical Chemistry have used a combination of metabolomics and machine learning to identify possible biomarkers that could both help diagnose COVID-19 and assess the risk of developing severe illness.
Story Tips from Johns Hopkins Experts on Covid-19
Hebrew Unievrsity researchers have found a less invasive and more accurate options for diagnoses using a simple blood test that detects DNA fragments.
Researchers in Japan have clarified the mechanism by which blood and lymphatic vessels remain separated after development. The characteristics and structures of these two vessel types are very similar, and how they maintain separation has remained unexplained for many years. In this study, researchers found that the molecule Folliculin (FLCN) in vascular endothelial cells acts as a gatekeeper to maintain separation between the two.
Although abnormal blood clotting has been identified as one of the primary causes of death from COVID-19, early treatment in an intensive care unit with therapeutic anticoagulation (anti-clotting) for adults who are critically ill with COVID-19 does not appear to improve chances of survival, and could do more harm than good by increasing the risk for major bleeding, a multicenter research group cautions.
New research has found that men who have the Western world's most common genetic disorder are more likely to develop dementia, compared to those without the faulty genes.
The U.S. Preventive Services Task Force (USPSTF) recommends against screening for asymptomatic carotid artery stenosis in the general adult population. Carotid artery stenosis is the narrowing of arteries that supply blood to the brain. This recommendation applies to adults without a history of transient ischemic attack, stroke or other neurologic signs or symptoms related to the carotid arteries.
Maternally derived antibodies are a key element of neonatal immunity. This study examined the association between maternal and neonatal SARS-CoV-2-specific antibody concentrations because understanding the dynamics of maternal antibody responses to SARS-CoV-2 infection during pregnancy and subsequent transplacental antibody transfer can inform neonatal management as well as maternal vaccination strategies.
Researchers at Children's Hospital of Philadelphia (CHOP) have developed a gene therapy vector for blood disorders like sickle cell disease and beta-thalassemia that is potentially safer and more effective than those currently used in gene therapy trials for those conditions. The vector, an engineered vehicle for delivering functional copies of the hemoglobin gene to correct a genetic abnormality, leads to the production of more hemoglobin with a lower dose, minimizing the risk of toxic side effects.