As reported in the journal Science, Leor Weinberger and his team at Gladstone Institutes have discovered a pathway they named discordant transcription through repair (DiThR, pronounced "dither"). The DiThR pathway appears to boost the noisiness of gene expression in stem cells and enhance their ability to differentiate.
Researchers at Cornell have developed a way to analyze how individual immune cells react to the bacteria that cause tuberculosis. It could pave the way for new vaccine strategies and provide insights into fighting other infectious diseases.
Hydrogels developed at Rice University mimic intestines when lined with epithelial cells. A study by Rice and Baylor College of Medicine proved hydrogels in various stiffnesses are valuable for learning the dynamics of pathogens that cause diarrhea and other intestinal diseases.
Every drug starts with the search for an active substance targeting disease-related key players. However, there is no perfect drug that affects the one target: no effect without side effects. A group led by Prof. Herbert Waldmann and Dr. Slava Ziegler at the Max Planck Institute of Molecular Physiology in Dortmund has now identified an unexpected effect for a group of characterized active substances: they all modulate cholesterol metabolism, a home-made problem, as it seems.
Over the last few decades, neurodegenerative diseases became one of the top 10 global causes of death. Researchers worldwide are making a strong effort to understand neurodegenerative diseases pathogenesis, which is essential to develop efficient treatments against these incurable diseases. A team of researchers found out the implication of lysosomes in the spread of Parkinson's disease.
Replication of SARS-CoV-2, the virus responsible for COVID-19, depends on a series of interactions between viral proteins and different cellular partners such as nucleic acids (DNA or RNA). Characterizing these interactions is crucial to elucidate the process of viral replication and identify new drugs for treating COVID-19.
Transplanting hematopoietic stem cells to treat cancers and other conditions carries with it the risk of developing cardio-cerebrovascular diseases (CCVD)--disorders affecting the blood vessels of the heart and brain. Although research on post-transplant CCVD is extensive, there is paucity of knowledge on the effects of pre-transplant CCVD on transplant outcomes. Now researchers in China suggest pre-transplant CCVD indirectly affects patient mortality and survival following transplant through their strong association with post-transplant CCVD.
A joint research team from the University of Hong Kong reported the development of a transferrable and integrative type I CRISPR-based platform that can efficiently edit the diverse clinical isolates of Pseudomonas aeruginosa, a superbug capable of infecting various tissues and organs and a major source of nosocomial infections. The technique can accelerate the identification of resistance determinants of multidrug resistant (MDR) pathogens and the development of novel anti-resistance strategies.
Some antibiotics appear to be effective against a form of skin cancer known as melanoma. Researchers at KU Leuven, Belgium, examined the effect of these antibiotics on patient-derived tumours in mice. Their findings were published in the Journal of Experimental Medicine.
Advances in microscopy reveal how the human genome organises itself in three-dimensional space at much higher resolution than previously possible. A new study finds that transcription generates a force that moves across DNA strands like ripples through water. The discovery may have future implications for the understanding of genetic diseases such as Cornelia de Lange syndrome, developmental disorders linked to chromatin folding, and open new avenues of research in genome fragility and cancer development.