Researchers from Tokyo Medical and Dental University (TMDU) identified proteins that bind to Toc-HDOs, double-stranded molecules combining RNA and DNA linked to a form of vitamin E, tocopherol, that have applications in gene silencing therapies. The team showed that Toc-HDOs work through a different mechanism to other DNA/RNA-based gene silencing approaches and identified four proteins involved in regulating their function. A greater understanding of Toc-HDO function could help with development of more effective gene silencing therapies.
- Nucleic Acids Research
- Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science