Researchers at ETH Zurich have developed a cell culture test to detect substances that are directly or indirectly harmful to embryos. Based on an existing test used for developing new drugs and chemicals, the augmented version is designed to help reduce the number of animal experiments.
The importance of aryl sulfides in biologically active compounds has led chemists to develop methods to synthesize them from carbon-sulfur bond forming reactions. The conventional reaction, however, uses thiols that are foul-smelling and toxic. Now, chemists from Waseda University, Japan, report a novel, thiol-free synthesis technique comprising a nickel-catalyzed aryl exchange between 2-pyridyl sulfide and aromatic esters, providing a versatile and inexpensive technology for both scientific and industrial applications.
The parasites that cause severe malaria are well-known for the sinister ways they infect humans, but new research may lead to drugs that could block one of their most reliable weapons: interference with the immune response.
A new approach to treating breast cancer kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases in bone, brain, liver and lungs. The newly developed drug, called ErSO, quickly shrinks even large tumors to undetectable levels.
A new Dartmouth-led study published this month in the New England Journal of Medicine sheds light on the role US health systems play concerning racial inequality in prescription pain medicine receipt.
Certain regions of the SARS-CoV-2 genome might be a suitable target for future drugs. This is what researchers at Goethe University, together with their collaborators in the international COVID-19-NMR consortium, have now discovered. With the help of dedicated substance libraries, they have identified several small molecules that bind to certain areas of the SARS-CoV-2 genome that are almost never altered by mutations.
A Michigan State University researcher is leading an international team of scientists to develop a low-cost, practical biopolymer dressing that helps heal chronic wounds.
Researchers at Children's Hospital of Philadelphia (CHOP) have developed a novel method for producing new antibiotics to combat resistant bacteria. Through an approach that would target bacteria with an antibiotic that is masked by a prodrug, which the bacteria would themselves remove, the researchers identified a method that would allow for development of new, effective antibiotics that could overcome issues of resistance. The findings were published today in eLife.
An experimental drug reported in Nature Communications suggests that a "path is clearly achievable" to treat currently untreatable cases of cystic fibrosis disease caused by nonsense mutations. This includes about 11 percent of cystic fibrosis patients, as well as patients with other genetic diseases, including Duchenne muscular dystrophy, β-thalassemia and numerous types of cancers, that are also caused by nonsense mutations.
An oral prodrug developed by a team of scientists led by Binghe Wang, Regents' Professor of Chemistry at Georgia State University, delivers carbon monoxide to protect against acute kidney injury, according to a new paper published in Chemical Science.