Antibody-drug conjugates developed are found to attack not only targeted tumor cells but also nontargeted 'bystanders.'
An innovative new device which can examine and separate single cells on the basis of their response to stimuli could boost personalized medicine and advance our understanding of our own molecular mechanisms.
Asymmetric three-component 1,2-oxytrifluoromethylations of styrenes were explored by using N-oxyphthalimide (NOPI) as the resulting benzylic radical anchor after cross-coupling by a CF3 radical under the catalyses of chiral N-salicylidene-derived oxovanadium(V) complexes. Unprecedented, four-component, and asymmetric radical 1,4-oxy-trifluoromethylation to olefins was also achieved. DFT calculations were performed to explain the enantioselectivity. The enantioselectivity profile was dominated by several noncovalent interactions between the intermediary vanadium(NOPI) complex and the resulting benzylic radical.
Research demonstrates how a hydrazone template can replace energy-intensive distillation to produce and isolate gamma-cyclodextrin -- a water-soluble chemical that attracts other molecules and is used to enhance food, pharmaceuticals, and a wide range of consumer products.
The use of statin therapy in adults 65 years old or older is not associated with incident dementia, mild cognitive impairment (MCI) or decline in individual cognition domains, according to a study published in the Journal of the American College of Cardiology (JACC).
A research team at the University of Hong Kong discovers that silver (Ag)-based antimicrobials can effectively combat antibiotic resistant Staphylococcus aureus by targeting multiple biological pathways via functional disruption of key proteins and can be further exploited to enhance the efficacy of conventional antibiotics as well as to resensitize methicillin-resistant Staphylococcus aureus (MRSA) to antibiotics.
Two recent studies led by researchers from the University of Minnesota Medical School add new evidence to the impact of how drug price increases affect US patients and the overall cost of health care.
Adding an immune checkpoint inhibitor to anti-HER2 treatment in breast cancer does not improve pathological complete response (pCR), according to the primary analysis of the IMpassion050 trial presented today during the ESMO Virtual Plenary. The phase III trial is the first to report data comparing a neoadjuvant anti-HER2 based regimen with or without the anti-PD-L1 antibody atezolizumab in patients with high-risk, HER2-positive early breast cancer.
In our study, we constructed a detecting platform based on TpTta-COF nanosheets and fluorescent probe. The TpTta-COF nanosheets can adsorb single-stranded DNA (ss-DNA) probes and quench the fluorescence of ss-DNA. The method enables to capture miR-205 sensitively in aqueous solution with a detection limit of 4.78 nM in the range 0-500 nM and R2 = 0.989, and the method offers great specificity in that it can distinguish the target miRNA from mismatch non-target miRNAs.
Osaka University researchers create an intelligent nanopore system sensitive enough to detect single SARS-CoV-2 virus particles. By training a machine-learning algorithm, the platform was able to identify between various coronaviruses in just five minutes. This work may lead to fast and accurate point-of-care testing for COVID and other communicable diseases.