Man's new best friend: What cats can teach us about human genetics and precision medicine
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Although cats have lived alongside humans for millennia, it remains a dogs' world. This bias has historically bled into science as well. It's time for cats to get their day, argues veterinary medicine expert Leslie Lyons (@LyonsLab) in a Forum published July 28 in the journal Trends in Genetics. Cats, she says, have the potential to be a valuable model organism for geneticists, as the feline genome is ordered similarly to humans.
Researchers have identified a rare class of genetic differences transmitted from parents without autism to their affected children with autism and determined that they are most prominent in "multiplex" families with more than one family member on the spectrum. These findings are reported in Recent ultra-rare inherited variants implicate new autism candidate risk genes, a new study published in Nature Genetics.
A genetic analysis of fruit in the mandarin family has unraveled a complex journey from the mountainous region of southern China to the markets of Okinawa, says researchers from the Okinawa Institute of Science and Technology Graduate University.
A new study led by an Iowa State University scientist sheds light on how organisms have evolved to address imbalances in sex chromosomes. The study looks at a species of softshell turtle, but the results could help to illuminate an important evolutionary process in many species. The research centers on a process known as sex chromosome dosage compensation.
St. Jude Children's Research Hospital study highlights the power of comprehensive whole genome, whole exome and RNA sequencing to better understand and treat each patient's cancer.
Researchers at Washington State University have recently identified a DNA region known as VNTR2-1 that appears to drive the activity of the telomerase gene, which has been shown to prevent aging in certain types of cells. Knowing how the telomerase gene is regulated and activated and why it is only active in certain cell types could someday be the key to understanding how humans age and how to stop the spread of cancer.
In the first wealth and longevity study to incorporate siblings and twin pair data, researchers from Northwestern University analyzed the midlife net worth of adults (mean age 46.7 years) and their mortality rates 24 years later. They discovered those with greater wealth at midlife tended to live longer.
Mount Sinai researchers have developed a therapeutic agent that shows high effectiveness in vitro at disrupting a biological pathway that helps cancer survive, according to a paper published in Cancer Discovery, a journal of the American Association for Cancer Research, in July.
In a new PLOS Genetics study, researchers have uncovered evidence showing that cattle are losing important environmental adaptations, losses the researchers attribute to a lack of genetic information available to farmers. After examining genetic material stretching back to the 1960s, they identified specific DNA variations associated with adaptations that could one day be used to create DNA tests for cattle -- tests that could tell farmers whether their cattle are suited for one environment or another.
After examining nearly the entire human genome for genetic changes that increase risk of aneurysm, researchers discovered a new change in the genetic code of a transcription factor.