Scientists seek to better understand protein folding to cure misfolding diseases, but this incredibly complex process requires sophisticated algorithms to identify the folding mechanisms. Computational biophysicists have proposed a new way to identify the most crucial factors for protein folding. They demonstrated the short simulation time of their approach on a small but intriguing protein, "GB1 beta-hairpin," in The Journal of Chemical Physics. The four novel intermediate folding states (MS1-4) identified by the team are shown here, along with the possible connecting pathways. The thickness of the interconnecting arrows reflect the likelihood that pathway occurs.