Changes in body core temperature (A) and hypothalamic interstitial PGE2 concentration (B) in mice injected with lipopolysaccharide (LPS). LPS was intraperitoneally injected to Slco2a1+/+ or Slco2a1-/- mice at time 0 hr. Body temperature was measured by monitoring colonic temperature. For PGE2 measurements, samples were collected by means of microdialysis, and subjected to LC-MS/MS analysis. (A) and (B) show mean values ± S.E.M of 10 and 6 mice in each group, respectively.