EGCG maintains neuronal cell cytoskeleton integrity. Methyl glyoxal treatment leads to glycation of actin and microtubules leading to hampered growth of neuritic extensions and microtubule organization. Microtubule stabilization by +TIP EB1 is also affected resulting in loss of cell morphology. In presence of EGCG, the actin rich neuritic extensions are enhanced which might help in neuronal connections. EGCG also maintains intact MTOC and thus microtubule mediated transport. EGCG also helps in microtubule polymerization via EB1 protein thus maintaining and rescuing overall cell integrity.
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