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Monitoring the impact of pneumococcal conjugate vaccination in The Gambia


Grant MacKenzie of the MRC Unit in The Gambia and colleagues describe in this week's PLoS Medicine how they set up a population-based surveillance system to assess the impact of pneumococcal conjugate vaccines (PCVs) on invasive pneumococcal disease (IPD) and radiological pneumonia in children in The Gambia. The surveillance system is expected to inform immunisation policy and serves as a potential model for those introducing routine PCV vaccination in diverse settings.

The authors state: "Evidence of sustained reduction of IPD and radiological pneumonia due to PCVs is important to justify their introduction and ongoing use. Identification of emerging pneumococcal serotypes may also assist the design of future PCVs."


Funding: Funded by GAVI alliance and the Bill & Melinda Gates Foundation. Neither of the funders had a role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

Competing Interests: The authors have declared that no competing interests exist.

Citation: Mackenzie GA, Plumb ID, Sambou S, Saha D, Uchendu U, et al. (2012) Monitoring the Introduction of Pneumococcal Conjugate Vaccines into West Africa: Design and Implementation of a Population-Based Surveillance System. PLoS Med 9(1): e1001161. doi:10.1371/journal.pmed.1001161

Grant MacKenzie
MRC Unit
Fajara and Basse stations
The Gambia
West Africa

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