Public Release: 

Antiviral protein links gut microbiota and allergies

Proceedings of the National Academy of Sciences

Researchers report that mice genetically deficient in a mitochondrial antiviral protein (MAVS) experienced significant alterations in gut microbiota, a condition termed dysbiosis, compared with wild-type mice, leading to increased intestinal permeability and bacterial migration within the body upon inflammatory challenge, as well as increased susceptibility to the murine model of human allergic contact dermatitis; the results suggest a mechanistic link between gut microbiota and allergies.


Article #17-22372: "MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype," by Emilie Plantamura et al.

MEDIA CONTACT: Marie-Cecile Michallet, Cancer Research Center of Lyon, FRANCE; e-mail:

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