科研人员报告说他们识别出了一种称为SynuClean-D的小分子,它能干扰淀粉样纤维并且抑制α-突触核蛋白的聚集,这两种物质都是帕金森病的致病过程;在使用动物神经退化模型的试验中,SynuClean-D减少了α-突触核蛋白的毒性,防止了淀粉样纤维的传播,并且逆转了多巴胺能神经原的退化,这提示SynuClean-D可能代表了一种可能的神经退化疗法。
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Proceedings of the National Academy of Sciences
科研人员报告说他们识别出了一种称为SynuClean-D的小分子,它能干扰淀粉样纤维并且抑制α-突触核蛋白的聚集,这两种物质都是帕金森病的致病过程;在使用动物神经退化模型的试验中,SynuClean-D减少了α-突触核蛋白的毒性,防止了淀粉样纤维的传播,并且逆转了多巴胺能神经原的退化,这提示SynuClean-D可能代表了一种可能的神经退化疗法。
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